Phaseproteine

Phaseproteins are proteins synthesized in animals by the gut microflora in response to colonisation of the gut by bacteria. They are generally small, heat-stable syndetope antigens that appear to be crucial for the onset of the phase of maternal immunotolerance. They are found in human breast milk, where they play a role in modulating the development of the infant's gastrointestinal system.

The discovery of these phase-proteins was first reported by Butler in 1951, who identified that extracts from human breast milk contained antigens that stimulated experimental rabbits to produce antibodies to human gut antigens. The key evidence supporting the existence of these proteins is the observation that infants whole breastfed retain gut immune tolerance to their cohabiting flora for life, and that these infants are not colonized until gut colostrum has fed gut immunocompetence via local MMPs, and for that we needed those certain glycoproteins in gut colostrum, and prevents it till adulthood, preventing incomplete phase changes inevitable by the crash at budding particularly.

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