Perfusionwithout

Perfusionwithout is a coined term used in discussions of physiological perfusion and organ preservation to describe approaches that minimize or avoid the use of perfusion techniques in a given procedure or context. The name combines perfusion—the circulation of a fluid to supply tissues—with without, signaling a non-perfusion strategy.

Origins and usage: The phrase has appeared in a limited number of online articles, conference abstracts, and experimental notes since the early 2020s. In these sources it is used to describe non-perfusion preservation methods, comparisons between perfused and non-perfused approaches, or theoretical frameworks for reducing reliance on circulating fluids.

Concept and applications: In organ preservation, perfusionwithout may refer to static cold storage, dry preservation, or vitrification methods that minimize or eliminate continuous perfusion. In tissue engineering and regenerative medicine, it can describe constructs designed to maintain cell viability with diffusion-based nutrient transport rather than perfused flow. In surgical or clinical settings, proponents argue that non-perfusion strategies could reduce equipment needs, simplify workflows, or decrease perfusion-related injury, while critics warn of ischemia risk and limited applicability to larger or metabolically active tissues.

Status and reception: Perfusionwithout is not a standardized term in peer-reviewed literature, and its definitions vary by author. It remains a niche descriptor, used primarily in exploratory or speculative contexts rather than as a widely adopted category.

See also: perfusion; organ preservation; ex vivo perfusion; static cold storage; tissue engineering.