PTPRZ

PTPRZ, also known as protein tyrosine phosphatase, receptor type Z, is a protein that in humans is encoded by the PTPRZ gene. This gene is part of the larger protein tyrosine phosphatase family, which plays crucial roles in cellular signaling by dephosphorylating tyrosine residues on target proteins. PTPRZ is a transmembrane protein, meaning it is embedded within the cell membrane and has a portion extending outside the cell and another portion inside.

The extracellular domain of PTPRZ is known to interact with other molecules, and its intracellular domain possesses the catalytic activity of a phosphatase. Research suggests that PTPRZ is involved in various developmental processes, including the development of the central nervous system. It has been implicated in neuronal differentiation and the regulation of cell growth and survival. Aberrant expression or function of PTPRZ has been linked to certain neurological disorders, highlighting its importance in maintaining proper brain function. The precise mechanisms by which PTPRZ exerts its effects are still under investigation, but it is believed to modulate signaling pathways that control cell behavior.