PTHrelaterat
PTHrelaterat refers to conditions, mechanisms, and molecules related to parathyroid hormone (PTH) and its related peptide PTHrP. The term commonly appears in medical literature to describe processes that influence calcium and phosphate homeostasis, bone remodeling, development, and certain cancers.
PTH is produced by the chief cells of the parathyroid glands. In response to low serum calcium,
PTHrP, or parathyroid hormone-related protein, is produced widely in fetal tissues and in various adult tissues.
Clinically, PTH-related abnormalities include hyperparathyroidism (excess PTH) and hypoparathyroidism (insufficient PTH). Hypercalcemia may arise from excessive
Treatment depends on the underlying cause: surgical removal of a diseased parathyroid gland in primary hyperparathyroidism;
See also: Parathyroid hormone, PTHrP, hyperparathyroidism, hypoparathyroidism, humoral hypercalcemia of malignancy.