PROM1
PROM1, also known as prominin-1 and CD133, is a pentaspan transmembrane glycoprotein encoded by the PROM1 gene. It is widely used as a marker to identify adult stem cells and cancer stem cells across multiple tissues, and it has been studied for its roles in development and disease.
The protein contains five transmembrane segments with two large extracellular loops, and the N- and C-termini
PROM1 is expressed in several stem and progenitor cell populations, including neural, hematopoietic, epithelial, and retinal
Clinical relevance for PROM1 includes inherited retinal diseases; specific mutations have been linked to cone-rod dystrophy
Genetically, PROM1 is located on chromosome 4 in humans (approximately 4p15.33) and exhibits multiple splice variants.