PRDX2

PRDX2, also known as peroxiredoxin-2, is a protein encoded by the PRDX2 gene. It is a member of the peroxiredoxin family, a group of antioxidant enzymes that play a crucial role in protecting cells from oxidative damage. These enzymes catalyze the reduction of hydrogen peroxide and organic hydroperoxides, thereby detoxifying reactive oxygen species (ROS).

The PRDX2 protein functions as a homodimer or homotetramer and is found in the cytoplasm of various cell types. It is involved in cellular processes such as redox signaling, immune response, and cell proliferation. Its antioxidant activity helps maintain cellular homeostasis and prevents damage to DNA, proteins, and lipids.

Dysregulation of PRDX2 has been implicated in the development and progression of several diseases, including cancer and neurodegenerative disorders. In cancer, PRDX2 can act as either a tumor suppressor or oncogene depending on the cellular context and stage of the disease. Its role in oxidative stress and cell survival makes it a potential therapeutic target for various conditions. Research continues to explore the multifaceted roles of PRDX2 in health and disease.