PPARreseptorit

PPARreseptorit, or Peroxisome Proliferator-Activated Receptors, are a family of ligand-activated transcription factors that play a crucial role in lipid metabolism and inflammation. They are classified into two subfamilies: PPAR-alpha, PPAR-delta, and PPAR-gamma. Each PPAR subtype is activated by specific ligands, which are small molecules that bind to the receptor and initiate a cascade of events leading to changes in gene expression.

PPAR-alpha is primarily activated by fatty acids and is involved in the regulation of lipid metabolism, particularly the oxidation of fatty acids. PPAR-delta is activated by fatty acids and certain eicosanoids, and it plays a role in the regulation of glucose and lipid metabolism. PPAR-gamma is activated by fatty acids and certain eicosanoids, and it is involved in the regulation of glucose and lipid metabolism, as well as inflammation.

PPARreseptorit are expressed in various tissues, including the liver, adipose tissue, and immune cells. They play a crucial role in maintaining metabolic homeostasis and are implicated in the development of metabolic disorders such as obesity, type 2 diabetes, and dyslipidemia. PPARreseptorit are also targets for drug development, with several PPAR agonists and antagonists being used to treat metabolic disorders and inflammatory diseases.