Home

PGL2

PGL-2 is a germline-associated protein in Caenorhabditis elegans. It is one of the components of P granules, cytoplasmic ribonucleoprotein assemblies that reside in the germline lineage. The protein is encoded by the pgl-2 gene and is related to other PGL family members, such as PGL-1 and PGL-3. During development, PGL-2 localizes to P granules in oocytes and early embryos and remains enriched in germ cells through larval and adult stages.

PGL-2 is involved in the organization and function of P granules, which are thought to participate in

Expression of pgl-2 is largely restricted to the germline, with its activity and localization modulated during

Genetic and cellular studies using loss-of-function and localization analyses have explored PGL-2’s role. Disruption of pgl-2

the
processing,
localization,
and
regulation
of
germline
RNAs.
Through
interactions
with
other
P
granule
proteins,
including
PGL-1,
PGL-3,
and
GLH
family
helicases,
PGL-2
is
believed
to
contribute
to
the
compartmentalization
and
regulation
of
germline
transcripts
and
related
processes.
development
and
in
response
to
cellular
conditions.
In
many
genetic
backgrounds,
PGL-2
is
thought
to
act
in
concert
with
other
P
granule
components
to
support
proper
germline
development
and
fertility.
can
perturb
P
granule
integrity
and
germline
development
and
may
result
in
fertility
defects
under
certain
conditions.
As
a
component
of
the
germline
RNA
regulatory
network
in
C.
elegans,
PGL-2
remains
a
focus
of
research
on
how
germline
RNA
control
is
organized
in
nematodes.