PDZ1

PDZ1 refers to the first of several PDZ domains found in the PSD-95 protein. PDZ domains are structural motifs that are commonly found in proteins and are involved in protein-protein interactions. They are approximately 90 amino acids in length and are characterized by a specific folded structure. The PSD-95 protein, also known as postsynaptic density-95, is a crucial scaffolding protein located at the postsynaptic density of excitatory synapses in the brain. It plays a vital role in organizing and anchoring neurotransmitter receptors and other signaling molecules at the synapse. PDZ1, along with PDZ2 and PDZ3 within PSD-95, mediates the binding of PSD-95 to specific target proteins. These target proteins typically contain a C-terminal sequence that is recognized by the PDZ domain. The interaction between PDZ1 and its binding partners contributes to the assembly and function of the postsynaptic density, influencing synaptic strength and plasticity. Specific proteins known to interact with PDZ1 include GluR1, a subunit of the AMPA receptor, and nNOS, neuronal nitric oxide synthase. These interactions are essential for proper synaptic transmission and neuronal signaling.