PDGFRta

PDGFRta, also known as Platelet-Derived Growth Factor Receptor Alpha subunit, is a transmembrane receptor tyrosine kinase. It is encoded by the PDGFR A gene in humans. PDGFRta is a member of the immunoglobulin superfamily of receptors and plays a crucial role in cellular growth, differentiation, and survival. It dimerizes upon binding to its ligands, which are members of the platelet-derived growth factor (PDGF) family, specifically PDGF-A, PDGF-C, and PDGF-D. Upon ligand binding, PDGFRta undergoes autophosphorylation, activating downstream signaling pathways such as the Ras/MAPK, PI3K/Akt, and PLC pathways. These pathways regulate a wide range of cellular processes. PDGFRta is expressed in various cell types, including fibroblasts, smooth muscle cells, and certain glial cells. Its involvement is critical during embryonic development, particularly in the development of the gastrointestinal tract and the formation of connective tissues. Aberrant PDGFRta signaling is implicated in the pathogenesis of several diseases, including various cancers and fibrotic disorders, making it a target for therapeutic intervention.