PARVB

PARVB is a gene symbol used in some public genomic resources to designate a member of the parvalbumin protein family, sometimes referred to as parvalbumin beta. However, there is no universally accepted gene model for PARVB, and major databases do not consistently treat PARVB as a distinct gene separate from PVALB. Because of this lack of consensus, there is no widely cited sequence, chromosomal location, or explicit functional characterization attributable solely to PARVB in standard references.

In practice, annotations that mention PARVB are often aligned with the parvalbumin locus or with related EF-hand calcium-binding proteins. The parvalbumin family consists of small cytosolic calcium-binding proteins that participate in buffering intracellular Ca2+ and shaping rapid signaling in neurons and muscle. If PARVB corresponds to a beta paralog of parvalbumin, it would be expected to share EF-hand motifs and calcium-binding properties, but specific expression patterns and physiological roles for a distinct PARVB product have not been established in authoritative sources.

Because of the inconsistent usage, researchers are advised to verify current identifiers in gene databases such as Ensembl, NCBI Gene, and UniProt when PARVB appears in data. The term can reflect historical nomenclature, misannotation, or species-specific annotations rather than a clearly defined separate gene.

See also: parvalbumin, PVALB.