Oxacillinázokat
Oxacillinázokat, also known as oxacillinases, are a group of beta-lactamase enzymes. These enzymes are produced by bacteria and play a crucial role in antibiotic resistance. Specifically, oxacillinases are responsible for hydrolyzing the beta-lactam ring of penicillin-derived antibiotics, including oxacillin, methicillin, and nafcillin. This enzymatic degradation renders these antibiotics ineffective, rendering the bacteria resistant to their action.
The genes encoding oxacillinases are often located on mobile genetic elements, such as plasmids, which facilitates
Detection of oxacillinase activity is important in clinical microbiology for guiding antibiotic treatment. Methods such as