Optiminen

Optiminen is a synthetic heterocyclic organic compound in the amide family with a fused bicyclic core related to tetrahydroquinazolinones. It has been described in medicinal chemistry literature as a versatile scaffold for exploring central nervous system activity and anti-inflammatory profiles. The compound is commonly cited with the formula C12H15NO3 and a molecular weight of about 213.26 g/mol. In its neutral form it appears as a white crystalline solid with a melting point reported around 132–136 C. It is sparingly soluble in water but dissolves in many organic solvents such as dimethyl sulfoxide and ethanol, with a predicted logP near 1.9 indicating moderate lipophilicity.

Optiminen can be prepared by a two-step sequence starting from an o-aminobenzamide derivative and an activated enone. An initial cyclization under acidic conditions yields the tetrahydroquinazolinone core, followed by selective reduction to introduce the saturated ring system characteristic of Optiminen. Various published routes differ in protecting-group strategies and substituent patterns, allowing small modifications to the phenyl substituent and the amide side chain.

Applications of Optiminen are primarily in early-stage drug discovery and chemical biology. Derivatives of the scaffold have been investigated for in vitro interactions with several central nervous system targets and for anti-inflammatory activity in cell-based assays. The compound has also been used as a building block in coordination chemistry studies, leveraging its amide functionality and heteroatoms to serve as a ligand in model systems.

Safety and status: Optiminen has no approved medical use and remains a research chemical. Handling requires standard laboratory safety practices for organic compounds, including proper ventilation and protective equipment. Because comprehensive safety evaluations are lacking, potential human exposure should be minimized and regulatory status may vary by jurisdiction.