OVCAR3

OVCAR3 is a human ovarian cancer cell line that is widely used in cancer research. It was established in 1980 from the malignant ascites of a 59-year-old Caucasian woman with serous adenocarcinoma of the ovary. OVCAR3 cells are considered a standard model for studying ovarian cancer due to their well-characterized biological properties and responsiveness to various chemotherapeutic agents.

These cells are adherent and grow as a monolayer in vitro. They express various markers associated with ovarian cancer, including CA-125, HER2, and estrogen receptors, although the expression levels can vary. OVCAR3 cells have been instrumental in understanding the mechanisms of ovarian cancer development, progression, and drug resistance. Researchers utilize OVCAR3 in studies investigating novel therapeutic targets, evaluating the efficacy of new drugs, and exploring the tumor microenvironment. Their reliability and reproducibility make them a valuable tool for preclinical research aimed at improving ovarian cancer treatment outcomes.