OOHF2

OOHF2, also known as Oocyte maturation factor 2, is a protein that plays a crucial role in the process of oocyte maturation. It is a member of the OOH family of proteins, which are involved in various cellular processes, including cell cycle regulation and apoptosis. OOHF2 is primarily expressed in the ovaries and is essential for the proper development and maturation of oocytes.

The gene encoding OOHF2 is located on chromosome 19q13.3 in humans. The protein is composed of 172 amino acids and has a molecular weight of approximately 19 kDa. OOHF2 is a secreted protein and is thought to act through a paracrine or autocrine mechanism.

OOHF2 has been shown to regulate the expression of several genes involved in oocyte maturation, including those encoding cyclins, cyclin-dependent kinases, and other cell cycle regulators. It also plays a role in the regulation of apoptosis in oocytes, which is important for the selection of the best-quality oocyte for fertilization.

Mutations in the OOHF2 gene have been associated with infertility and premature ovarian failure. These mutations can lead to impaired oocyte maturation and reduced fertility. However, the exact mechanisms by which OOHF2 mutations cause infertility are not fully understood.

OOHF2 is a relatively newly discovered protein, and much remains to be learned about its function and regulation. However, its role in oocyte maturation and its association with infertility make it an important area of research in reproductive biology.