Necroptotic

Necroptotic is a term used in biology and medicine to describe a type of cell death that combines features of both necrosis and apoptosis. Necrosis is characterized by cell swelling, membrane rupture, and the release of intracellular contents, while apoptosis involves a controlled, programmed cell death with characteristic morphological changes and the formation of apoptotic bodies. Necroptosis, on the other hand, is a form of regulated necrosis that occurs in response to specific stimuli, such as certain cytokines or stress signals. It is mediated by the RIPK3 (Receptor-interacting protein kinase 3) complex and is often associated with inflammatory responses and tissue damage. Necroptotic cell death is thought to play a role in various pathological conditions, including ischemia-reperfusion injury, sepsis, and certain types of cancer. The study of necroptosis is an active area of research, with ongoing efforts to understand its mechanisms and potential as a therapeutic target.