NaKATPáz
Na+/K+-ATPase, also known as the NaK-ATPase, is a membrane-bound enzyme that uses energy from ATP hydrolysis to pump sodium and potassium ions across the plasma membrane against their concentration gradients. In animal cells, it exports three Na+ ions to the extracellular space and imports two K+ ions into the cytosol for each cycle, making the pump electrogenic and helping establish the resting membrane potential and cell volume homeostasis. The pump is a heteromer composed mainly of a catalytic α subunit and a glycosylated β subunit; in vertebrates multiple α isoforms (α1, α2, α3, α4) and one or more β isoforms are expressed in tissue-specific patterns. Some auxiliary γ-subunits or FXYD proteins modulate activity.
Mechanistically, Na+/K+-ATPase belongs to the P-type ATPase family. It binds three Na+ ions on the cytoplasmic
Physiological roles include maintenance of electrochemical gradients for action potentials, driving secondary active transport, and regulating