NTF4

NTF4, also known as Ntrk2 or TrkB, is a gene that encodes a receptor tyrosine kinase. This receptor plays a crucial role in the development and function of the nervous system. NTF4 is activated by neurotrophins, a family of proteins that promote the survival, growth, and differentiation of neurons. Specifically, NTF4 is the primary receptor for brain-derived neurotrophic factor (BDNF), but it can also bind to neurotrophin-3 (NT-3) with lower affinity.

Upon binding of its ligand, NTF4 undergoes dimerization and autophosphorylation, initiating downstream signaling pathways. These pathways are involved in a variety of cellular processes, including synaptic plasticity, learning, memory, and neuronal survival. Dysregulation of NTF4 signaling has been implicated in various neurological and psychiatric disorders, such as Alzheimer's disease, depression, and schizophrenia. Research into NTF4 continues to explore its therapeutic potential for treating these conditions.