NR4B1

NR4B1, also known as nuclear receptor subfamily 4 group 1 member 1, is a gene that encodes a protein belonging to the steroid hormone receptor superfamily. These receptors are transcription factors that regulate gene expression in response to various stimuli. The NR4B1 protein, like other nuclear receptors, is characterized by a DNA-binding domain and a ligand-binding domain, although its specific natural ligand is not yet fully elucidated.

The NR4B1 gene is expressed in a wide range of tissues and plays roles in cellular processes such as proliferation, differentiation, and apoptosis. It has been implicated in the development and progression of several diseases, including cancer. Research suggests that NR4B1 can act as either an oncogene or a tumor suppressor depending on the cellular context and the specific type of cancer.

In some cancers, NR4B1 expression is elevated and promotes tumor growth and metastasis. Conversely, in other malignancies, it may exhibit tumor-suppressive functions. The complex role of NR4B1 in cancer highlights the intricate nature of gene regulation in disease. Further research is ongoing to fully understand the mechanisms by which NR4B1 contributes to cellular functions and disease pathogenesis, with the aim of identifying potential therapeutic targets.