NNdimethylation
NNdimethylation is a chemical modification involving the sequential addition of two methyl groups to the nitrogen atom(s) of a molecule, most commonly observed in organic and biochemical contexts. This process typically refers to the dimethylation of amine groups, resulting in N,N-dimethyl derivatives. It is a common post-translational modification in proteins, wherein it alters the chemical properties and activity of target molecules.
In biochemistry, NN-dimethylation frequently occurs on lysine and arginine residues within histones, playing a crucial role
Synthetic NN-dimethylation is also employed in organic chemistry, particularly in the synthesis of pharmaceuticals and fine
The biological significance of NN-dimethylation lies in its ability to modulate molecular functions, including enzyme activity,
Overall, NN-dimethylation is a fundamental chemical modification with diverse roles in biological regulation and synthetic chemistry,