NM23H2

NM23H2, also known as NME2, is a human gene that encodes a protein belonging to the nucleoside diphosphate kinase family. These enzymes are primarily involved in the phosphorylation of nucleoside diphosphates to nucleoside triphosphates, which are essential building blocks for DNA and RNA synthesis. NM23H2 is a ubiquitous protein found in various tissues and plays a role in diverse cellular processes beyond its enzymatic activity.

The protein encoded by NM23H2 has been implicated in a range of cellular functions, including cell proliferation, differentiation, and apoptosis. It is also known to interact with other proteins, suggesting a role in complex signaling pathways. Furthermore, NM23H2 has been linked to metastasis in certain cancers, with its expression levels sometimes correlating with the invasive and metastatic potential of tumor cells. Research has explored its involvement in developmental processes and its potential as a therapeutic target in cancer treatment. While its nucleoside diphosphate kinase activity is well-established, ongoing investigations continue to uncover additional non-enzymatic functions that contribute to its multifaceted biological roles.