NK1antagonister
NK1antagonister, also known as neurokinin-1 receptor antagonists, are a class of drugs that work by blocking the action of substance P, a neuropeptide involved in various physiological processes. Substance P binds to the neurokinin-1 (NK1) receptor, and when this receptor is activated, it can trigger responses such as pain, inflammation, and nausea. NK1 antagonists prevent substance P from binding to its receptor, thereby mitigating these effects.
The primary clinical application for NK1 antagonists has been in the prevention of chemotherapy-induced nausea and
The development of NK1 antagonists has been a significant advancement in supportive care for cancer patients,