NECL2

NECL2, also known as Neural Cell Adhesion Molecule L2, is a member of the L1 family of cell adhesion molecules. These molecules play crucial roles in the nervous system, particularly in cell-cell recognition and adhesion. NECL2 is a type I transmembrane glycoprotein. It is involved in the development and maintenance of neuronal structures, including axon guidance and fasciculation.

The gene encoding NECL2 is located on human chromosome 11q23.1. This protein is expressed in various tissues, with a prominent presence in the central and peripheral nervous systems. It is also found in some non-neuronal tissues like the kidney and liver. NECL2 interacts with other cell adhesion molecules and extracellular matrix proteins, contributing to the complex signaling pathways that govern cell behavior.

Research suggests that NECL2 is implicated in several neurological processes. Its involvement in neurite outgrowth and synapse formation points to its significance in neuronal connectivity. Aberrations in NECL2 expression or function have been linked to certain neurological disorders, though the exact mechanisms are still under investigation. Further studies are ongoing to fully elucidate the diverse roles of NECL2 in both normal physiology and disease pathogenesis.