NBDS
NBDs, or nucleotide-binding domains, are conserved protein domains that bind and hydrolyze nucleotide triphosphates, most commonly ATP or GTP. They function as energy transducers that drive conformational changes essential for the activity of many proteins, including transporters, helicases, and motor enzymes. In many proteins, an NBD is one module among others, forming a modular architecture that couples nucleotide hydrolysis to substrate processing, transport, or remodeling activities.
Most NBDs belong to the P-loop NTPase superfamily and contain several conserved motifs. The Walker A motif
NBDs are widespread across life and appear in diverse systems. Major examples include bacterial and eukaryotic