NADPNADPHsystemene
NADP+/NADPH is a pair of coenzymes used as key electron carriers in cellular metabolism. Unlike NAD+/NADH, which primarily support energy production, the NADP+/NADPH system provides reducing power for biosynthetic processes and for maintaining cellular redox balance. NADPH is the reduced form; NADP+ is the oxidized form. The interconversion between these forms is driven by various dehydrogenases and reductases in different cellular compartments.
In photosynthetic organisms, NADP+ accepts electrons during the light-dependent reactions of photosynthesis to form NADPH. The
In non-photosynthetic cells, NADPH mainly arises from the pentose phosphate pathway, malic enzyme, isocitrate dehydrogenase, and
Clinical and physiological relevance includes the dependence of redox-sensitive processes on adequate NADPH levels. Defects in