Methyltriflat

Methyltriflat is not a widely recognized chemical name in standard reference works. Searches of major chemical databases yield no CAS number or universally accepted structure under this spelling, suggesting it may be a typographical error or a local project name. The term could also refer to a methyl triflate–type reagent, whose name is sometimes confused in informal writing.

If the term is intended to denote methyl triflate (MeOTf), it is a powerful methylating agent used in organic synthesis. It is the methyl ester of triflic acid and is typically employed to transfer a methyl group to oxygen, nitrogen, or sulfur nucleophiles, forming methyl ethers, amines, or thioethers. MeOTf is highly reactive and moisture sensitive; it is commonly supplied as a dry solution or neat under an inert atmosphere and requires strictly dry solvents and exclusion of water. In practice, it is used in a variety of methylation reactions that proceed readily under mild conditions with appropriate catalysts or bases.

Handling and safety considerations are important. MeOTf is corrosive and toxic; contact with skin or eyes can cause severe irritation, and inhalation of vapors can be harmful. It reacts exothermically with water and many common solvents, releasing corrosive byproducts. Appropriate personal protective equipment, a well-ventilated fume hood, and proper waste disposal are essential. Storage is in tightly closed, dry containers, typically under inert gas and away from moisture or incompatibles.