Methimazol
Methimazole is an antithyroid medication in the thionamide class used to treat hyperthyroidism. It works by inhibiting thyroid peroxidase, the enzyme that catalyzes iodination of tyrosine residues and the coupling of iodotyrosines in thyroglobulin. By blocking these steps, methimazole reduces the synthesis of thyroid hormones T4 and T3. It has little effect on the peripheral conversion of T4 to T3, a distinction from some other thionamides.
Common indications include Graves’ disease, toxic multinodular goiter, and solitary toxic nodules. It is often used
Administration and dosing: methimazole is given orally, with or without food. Dosing is individualized; typical adult
Monitoring and safety: routine monitoring of thyroid function and complete blood counts is recommended. Serious adverse
Availability and alternatives: methimazole is marketed under various brand names in different countries (for example Tapazole