MIAPE

MIAPE, or Minimum Information About a Proteomics Experiment, is a set of guidelines developed by the Proteomics Standards Initiative (PSI) of the Human Proteome Organization (HUPO). The aim is to specify the minimum information that should accompany a proteomics experiment to enable interpretation, reproduction, and reuse of results.

The guidelines cover the essential elements of a proteomics study, including experimental design, sample description, preparation procedures, analytical methods, instrumentation, data acquisition, data processing, and reporting of results. MIAPE is organized into modular components that can be updated as technologies evolve, with modules for gel-based proteomics, mass spectrometry, and protein or peptide identification and quantitation. Each module presets the metadata elements that should be captured, such as instrument settings, software versions, and data processing parameters.

Adoption and impact: MIAPE is widely used by journals and public data repositories to structure submissions and facilitate data sharing. It complements established data formats such as mzML, mzIdentML, and mzTab and supports interoperability of proteomics data across platforms. The PSI-HUPO guidelines underpin data submission to repositories like PRIDE and help improve data quality and reusability within the proteomics community.

See also: Proteomics Standards Initiative, HUPO, mzML, mzIdentML, mzTab, PRIDE.