MCPIP1

MCPIP1, also known as Monocyte chemotactic protein-induced protein 1, is a protein encoded by the MCPIP1 gene. It is a member of the zinc-finger protein family and plays a role in regulating cellular responses to stress and inflammation. MCPIP1 contains a UBL-like domain, a zinc-finger domain, and a RING-type zinc-finger motif, suggesting it has E3 ubiquitin ligase activity.

The expression of MCPIP1 is induced by inflammatory stimuli, such as tumor necrosis factor-alpha (TNF-α) and lipopolysaccharide (LPS). It is primarily found in immune cells, including monocytes and macrophages. Research suggests that MCPIP1 is involved in various cellular processes, including apoptosis, autophagy, and cytokine production.

Functional studies have indicated that MCPIP1 can act as a negative regulator of inflammatory signaling pathways, including the NF-κB pathway. It has been shown to deubiquitinate key signaling molecules, thereby modulating their activity. Furthermore, MCPIP1 has been implicated in the pathogenesis of several diseases, including autoimmune disorders, cardiovascular diseases, and cancer. Its precise roles and mechanisms of action are still under active investigation.