MBD14

MBD14 is a protein that contains a methyl-CpG-binding domain (MBD) and is part of the broader family of MBD proteins that interpret DNA methylation signals. Members of this family typically bind methylated CpG dinucleotides in a sequence-independent manner and recruit chromatin-modifying complexes, affecting transcription, DNA repair, and genome stability.

Potentially, MBD14 exhibits similar properties, but its exact function and partners remain to be established. In some species, MBD14 has been annotated as a less characterized or predicted protein with an MBD motif rather than a fully defined gene.

Structural features: The canonical MBD is about 70-80 amino acids forming a fold that recognizes methyl-CpG. Many MBD proteins also harbor transcriptional repressor or interaction motifs; however, the domain organization of MBD14 varies by species.

Evolution and genomics: The presence of MBD14-like sequences has been reported in multiple vertebrate and invertebrate genomes, but conservation and functional orthology to well-studied MBDs (MBD1-6) are not well defined.

Function and research status: There is limited experimental data for MBD14. Where studied, researchers examine expression patterns and subcellular localization; knockdown or knockout studies are needed to determine its role in development, differentiation, or DNA methylation pathways.

Related topics include the MBD protein family and the best-characterized members MBD1–MBD6 and MBD4.