MAP1B

MAP1B, or Microtubule-associated protein 1B, is a protein that plays a crucial role in the organization and stabilization of microtubules within neurons. Microtubules are essential components of the cytoskeleton, providing structural support and acting as tracks for intracellular transport. MAP1B is particularly important during neuronal development, where it influences neurite outgrowth, extension, and the formation of synaptic connections.

This protein is part of the MAP1 family, which also includes MAP1A, MAP1LC3 (LC3), and MAP1ALS. MAP1B interacts with microtubules through its light chain, which binds to tubulin subunits. Its expression is high in developing nervous systems and decreases in adulthood. Research suggests that MAP1B is involved in processes such as axonal guidance and the maintenance of neuronal architecture. Dysregulation of MAP1B has been implicated in certain neurodevelopmental and neurodegenerative disorders, highlighting its significance in neuronal health and function. The precise molecular mechanisms by which MAP1B exerts its effects are still under active investigation.