LTypKalziumkanäle
LTypKalziumkanäle, also known as L-type calcium channels, are a class of voltage-gated ion channels that play a crucial role in various physiological processes. These channels are primarily permeable to calcium ions (Ca2+) and are characterized by their unique biophysical properties and pharmacological sensitivities. They are widely distributed throughout the body, with significant expression in the heart, smooth muscle, and endocrine glands.
The "L" in LTypKalziumkanäle stands for "long-lasting" because the calcium current flowing through these channels deactivates
In cardiac muscle, L-type calcium channels are responsible for the influx of calcium during the plateau phase
Pharmacologically, L-type calcium channels are targets for several important drugs. Dihydropyridines, such as nifedipine and amlodipine,