LIFR
Leukemia inhibitory factor receptor (LIFR), also known as the LIF receptor, is a transmembrane glycoprotein that constitutes part of the type I cytokine receptor family. The human LIFR gene encodes the receptor subunit that together with gp130 (IL6ST) forms the functional receptor for leukemia inhibitory factor and related cytokines. The receptor complex is activated when a LIF-family cytokine binds to LIFR, recruiting gp130 and initiating intracellular signaling.
Signaling: The LIFR-gp130 receptor activates JAK kinases, leading to phosphorylation and activation of STAT transcription factors
Biological roles: In development and homeostasis, LIFR signaling supports neural development and maintenance, hematopoiesis, bone remodeling,
Clinical significance: Germline mutations in LIFR cause Stuve-Wiedemann syndrome, a severe skeletal dysplasia with hypotonia and