LH1PLOD1

LH1PLOD1 is a designation that appears in a limited set of genomic annotations to denote a putative read-through transcript or gene fusion involving LH1 (lysyl hydroxylase 1) and PLOD1. LH1 and PLOD1 refer to the same enzyme, lysyl hydroxylase 1, which participates in the post-translational modification of collagen. Because these names describe the same gene, the idea of a genuine LH1-PLOD1 fusion is not well supported by experimental evidence, and some databases treat this annotation as an artifact rather than a validated transcript.

Genomic context and transcriptional status of LH1PLOD1 are not consistently defined across resources. Entries that mention LH1PLOD1 often describe a read-through event at the gene boundary, but coordinates, exon structure, and transcription start sites are not uniformly reported. Validation at the RNA level (for example by RT-PCR) and at the protein level has not been broadly demonstrated.

Expression data for LH1PLOD1, when present in public datasets, tend to indicate low or sporadic levels with no clear tissue specificity established. There is currently no independent confirmation of a translated product and no proven functional role attributed to LH1PLOD1.

Clinical relevance and disease associations for LH1PLOD1 have not been established. At present, the designation is treated cautiously as a potential annotation artifact or a non-validated read-through, rather than a recognized biological transcript with known impact.

See also: PLOD1, lysyl hydroxylase, read-through transcripts, gene fusion.