LAP2s

LAP2s refers to the Lamin-associated proteins 2 family. These are a group of inner nuclear membrane proteins that play a crucial role in nuclear organization and function. They are integral membrane proteins that interact with lamins, which are components of the nuclear lamina. The LAP2 family consists of several isoforms, generated through alternative splicing and different start sites. These isoforms have distinct subcellular localizations and functional specificities.

LAP2 proteins are involved in a variety of cellular processes. They are key regulators of nuclear envelope formation and reassembly during mitosis. They also contribute to chromatin organization by interacting with specific DNA regions and associated proteins. This interaction helps maintain the structural integrity of the nucleus and influences gene expression. Furthermore, LAP2 proteins have been implicated in cell differentiation, apoptosis, and DNA repair. Aberrant expression or function of LAP2s has been linked to certain diseases, including some forms of cancer and neurological disorders. Research continues to explore the multifaceted roles of LAP2 proteins in both normal cellular physiology and disease pathogenesis.