Körnerzellschicht

Körnerzellschicht, also known as the granular cell layer, is a histological term referring to a specific layer of cells found in certain tissues. In the context of the epidermis, it is the third stratum from the bottom, located above the stratum spinosum and below the stratum lucidum. This layer is characterized by the presence of flattened cells that contain keratohyalin granules. These granules are precursors to keratin, the tough fibrous protein that forms the outer protective layer of the skin. The cells in the Körnerzellschicht undergo a process of keratinization, where their nuclei and organelles disintegrate, and their cytoplasm becomes filled with keratin filaments. This process is essential for the formation of the protective barrier of the skin. The thickness of the Körnerzellschicht can vary depending on the location on the body and the thickness of the epidermis. It is generally thicker in areas of high friction or pressure, such as the palms of the hands and the soles of the feet. The presence and appearance of the Körnerzellschicht are important diagnostic features in dermatopathology. Abnormalities in its formation or structure can be indicative of various skin conditions.