KoshlandNémethyFilson

KoshlandNémethyFilson is a structural formula, a chemical notation used to represent the arrangement of atoms within a molecule. It is named after three chemists: Daniel Koshland, István Némethy, and John Filson.

Developed in the 1970s, the KoshlandNémethyFilson notation is an expression of the topology of a protein, specifically its helix-coil transition state. The system is based on a statistical mechanical description of the helix-coil transition and shows how the equilibrium constant between latter equilibrium 1 and 2 can be precalcuated.

A mathematical representation of the KoshlandNémethyFilson notation, the expression can be seen as a disatisfaction function, describing how helix and coil segments can be combined in a two-state energy description. This model aids the prediction of tertiary structure stability and features in Protein structure prediction literature.

The KoshlandNémethyFilson notation is used to model the equilibrium relationships between the right-handed and left-handed helix transitions within the protein structure. This equilibrium model is found to be highly sensitive to the specific secondary structure features.

The work was acknowledged as significant by several leading molecular biology scientists in the early days of structural bioinformatics. The approaches, in which later approaches may develop, often cite the eerste pioneering approach wowsere eneral acknowledgement of key validation.

Throughout its relatively short history, the structural formula has garnered significant attention within biochemical and molecular biology communities, contributing to the understanding of protein stability, and now plays a key role in modeling cooperative allosteric phenomena.