Kinetokoren
Kinetochores (kinetokoren) are multiprotein structures located at the centromeres of chromosomes in most eukaryotic cells. They form the critical link between chromosomes and the spindle apparatus, enabling proper alignment and segregation during cell division, including mitosis and meiosis.
The kinetochore is organized into inner and outer components. The centromeric chromatin contains the histone variant
Functionally, kinetochores mediate the capture of dynamic microtubules and generate force for chromosome movement. Attachments are
Regulation is essential to fidelity. The spindle assembly checkpoint monitors kinetochore attachments and prevents anaphase onset
Clinical relevance includes links between kinetochore dysfunction and aneuploidy, cancer, and developmental disorders. Ongoing research investigates