Ketoximes
Ketoximes are oximes derived from ketones, formed by the condensation of a ketone with hydroxylamine. The general structure is R1R2C=NOH, where the carbonyl carbon bears two carbon substituents (R1 and R2) from the parent ketone. Ketoximes can exist as E and Z isomers about the C=N bond, and the isomer distribution can influence reactivity and properties.
Preparation methods typically involve reacting a ketone with hydroxylamine or hydroxylamine hydrochloride in the presence of
Key reactions and transformations of ketoximes include dehydration to nitriles, using dehydrating reagents such as POCl3,
Representative examples include acetone oxime (CH3)2C=NOH and benzophenone oxime Ph2C=NOH. Ketoximes thus function as versatile intermediates