Keratiiniverkon

Keratiiniverkon, often referred to as keratin network, is a term used in the context of cellular biology and protein structures. It describes a complex three-dimensional arrangement of keratin proteins within cells, particularly in epithelial tissues. Keratin is a fibrous structural protein that provides mechanical strength and integrity to cells and tissues. The interconnected network of keratin filaments, also known as intermediate filaments, forms a robust intracellular scaffold. This scaffold plays a crucial role in maintaining cell shape, resisting mechanical stress, and facilitating cell-cell adhesion.

The formation of the keratin network is a dynamic process involving the polymerization of keratin monomers into coiled-coil dimers, which then assemble into protofilaments and ultimately into the characteristic 8-10 nanometer diameter intermediate filaments. These filaments are then cross-linked and interconnected, creating a resilient meshwork throughout the cytoplasm. Different types of keratin proteins exist, and their specific composition determines the properties of the keratin network in various tissues. Disruptions or mutations in keratin genes can lead to a range of genetic disorders known as keratinopathies, affecting the skin, hair, nails, and other epithelial structures. The keratin network is therefore essential for cellular and tissue function, and its integrity is vital for overall health.