Kanamycin
Kanamycin is an aminoglycoside antibiotic produced by the bacterium Streptomyces kanamyceticus. It inhibits bacterial protein synthesis by binding irreversibly to the 30S ribosomal subunit, causing misreading of mRNA and blocking initiation, which leads to bactericidal effects against susceptible organisms.
The antibiotic has good activity against many Gram-negative bacteria, including Enterobacteriaceae and Pseudomonas species, with variable
Administration and use: Kanamycin is poorly absorbed from the gastrointestinal tract, so systemic infections are treated
Adverse effects and safety: Major toxicities include nephrotoxicity and ototoxicity (cochlear and vestibular), which can be
Resistance: Bacteria may develop resistance through aminoglycoside-modifying enzymes, methylation of the ribosomal target, or reduced uptake,