JAKSTATSignale
JAKSTATSignale, commonly written as JAK-STAT signaling, denotes a signal transduction pathway that transmits information from extracellular cytokines and growth factors to the nucleus via a JAK-STAT cascade. The core components are the Janus kinases (JAK1-3 and TYK2) bound to type I and II cytokine receptors and the STAT family transcription factors (STAT1-6).
Activation occurs when ligands bind receptors, causing receptor dimerization and JAK activation; JAKs phosphorylate receptor cytoplasmic
Cytokines such as IL-6, IL-2, IFN-γ, and growth factors utilize JAK-STAT signaling; specifics include IL-6 family
Physiological roles of JAK-STAT signaling include hematopoiesis, immune responses, inflammation, and development. Dysregulation or mutations (for
Therapeutic modulation includes JAK inhibitors (jakinibs) such as ruxolitinib (JAK1/2), baricitinib (JAK1/2), and tofacitinib (JAK1/3). These