Isopropylated
Isopropylated refers to a chemical modification where an isopropyl group, which is a branched three-carbon alkyl group with the formula (CH3)2CH−, is attached to a molecule. This process is known as isopropylation and can be achieved through various chemical reactions, such as Friedel-Crafts alkylation or nucleophilic substitution. The addition of an isopropyl group can significantly alter the physical and chemical properties of the parent molecule. For instance, it can increase lipophilicity, affecting solubility and how the molecule interacts with biological membranes. It can also influence the molecule's reactivity, steric hindrance, and conformation.
In organic chemistry, isopropylation is a common synthetic strategy used to create more complex molecules or