Integriners
Integriners are a class of proteins that belong to the integrin family, which are heterodimeric transmembrane glycoproteins. They play a crucial role in cell adhesion, migration, and signaling. Integriners are composed of an alpha (α) and a beta (β) subunit, each of which is a single-pass transmembrane protein. The α subunit is non-covalently associated with the β subunit, which contains the transmembrane and cytoplasmic domains.
Integriners are involved in various biological processes, including cell adhesion to the extracellular matrix (ECM), cell-cell
Integriners are classified into several subfamilies based on their β subunits. The most well-known subfamily is the
Integriners are also involved in immune responses. For example, the α4β1 integrin is expressed on the surface
Integriners are potential targets for therapeutic intervention in various diseases. For example, inhibiting integrin-mediated adhesion has