InsG

InsG is an abbreviation that appears in various scientific literatures, but it does not have a single universal meaning. Its interpretation depends on the field and the context in which it is used.

In genetics and genomics, InsG commonly denotes an insertion event involving guanine (G) nucleotides. In sequence-variation descriptions aligned with HGVS nomenclature, an insertion described as insG indicates that a single G nucleotide has been inserted at a specified position. The exact genomic coordinates and effect on the reading frame must be stated alongside.

In protein engineering and molecular biology, InsG may be used to indicate the insertion of a glycine residue (G) into a polypeptide, either in-frame or causing a frameshift depending on the reading frame and number of residues inserted. The practical meaning is defined by the experimental design and notation used by the authors.

In microbiology and genomics, some studies label a particular insertion sequence or transposable element as InsG, as an internal code within that study’s dataset. These labels are not standardized across the field and should be interpreted from the associated methods or genome annotation.

See also: HGVS nomenclature, insertion mutation, transposable element, glycine insertion.