Indolinones
Indolinones are a family of heterocyclic compounds that consist of a benzene ring fused to a five‑membered lactam ring, giving a bicyclic system. The parent structure is often referred to as indolin-2-one or 2-indolinone, a carbonyl-containing derivative of the indoline framework. Substituents at various positions on the benzene ring or on the lactam nitrogen expand this family into a wide range of indolinone derivatives.
The core feature of indolinones is the fusion of a benzene ring with a γ-lactam ring bearing
Synthesis and reactivity of indolinones are well developed in organic chemistry. Common routes include cyclization of
Applications focus on the indolinone scaffold as a versatile platform in medicinal chemistry. Many derivatives exhibit