Igf2H19

Igf2H19 is a term encountered in some genomic annotations that is used to refer to a region or transcript associated with the IGF2-H19 imprinted gene locus. It is not a widely established, standalone gene name in major reference databases, and its exact identity can vary between studies or annotation pipelines.

Genomic context at the IGF2-H19 locus: In humans and other mammals, this region lies on chromosome 11p15.5 and comprises the insulin-like growth factor 2 (IGF2) gene and the H19 long noncoding RNA gene, arranged in an imprinting cluster. IGF2 is typically paternally expressed, while H19 is expressed from the maternal allele. The region is regulated by imprinting control elements and differentially methylated regions, which influence the expression balance between IGF2 and H19 in a tissue- and development-dependent manner.

Potential roles and interpretation: If Igf2H19 represents a transcript or regulatory element within the IGF2-H19 region, it may reflect the regulatory interactions that govern growth signaling and development. IGF2 encodes a growth factor that activates signaling pathways promoting cell proliferation, whereas H19 can act as a long noncoding RNA and generate regulatory effects, including microRNA production such as miR-675 in some contexts. Dysregulation of imprinting at this locus is associated with developmental disorders and cancer, highlighting the clinical relevance of proper IGF2-H19 regulation.

Regulatory notes and research use: Because Igf2H19 is not a universally standardized gene symbol, researchers should verify its annotation against current genome builds and databases (for example, Ensembl or RefSeq) to determine whether it is coding or noncoding, its exact coordinates, and its relation to IGF2 and H19 transcripts in the studied tissue or species.