IgGTransport
IgGTransport refers to the movement of immunoglobulin G (IgG) across cellular barriers, enabling distribution, immune surveillance, and the maintenance of serum IgG levels. The central mechanism is neonatal Fc receptor (FcRn)–mediated transcytosis. IgG binds FcRn in acidic endosomes after cellular uptake; FcRn protects IgG from lysosomal degradation and releases it at the neutral pH of the blood or basolateral surfaces. This recycling process extends IgG’s half-life and allows selective trafficking between compartments, contributing to the steady-state concentration of IgG in circulation and tissues.
In physiological contexts, FcRn-driven transport is critical for maternal to fetal IgG transfer in pregnancy. FcRn
Clinically, IgGTransport influences the pharmacokinetics of therapeutic antibodies and intravenous immunoglobulin (IVIG). Modulating FcRn activity can