IPSPpotentiaaleja

IPSPpotentiaaleja, or inhibitory postsynaptic potentials, are transient hyperpolarizations of the postsynaptic membrane of a neuron. These potentials occur when a neurotransmitter binds to receptors on the postsynaptic neuron, leading to the opening of ion channels permeable to anions, such as chloride ions. The influx of negatively charged chloride ions into the cell makes the inside of the neuron more negative, thus increasing the membrane potential's distance from the firing threshold.

IPSPs are a crucial mechanism for regulating neuronal excitability. By counteracting excitatory postsynaptic potentials (EPSPs), which depolarize the membrane, IPSPs make it less likely that the postsynaptic neuron will fire an action potential. This inhibitory influence plays a vital role in neural circuits, allowing for fine-tuning of signal transmission, pattern formation, and preventing uncontrolled neuronal firing. Different neurotransmitters, like gamma-aminobutyric acid (GABA) and glycine, are commonly associated with mediating IPSPs in the central nervous system. The amplitude and duration of an IPSP depend on factors such as the amount of neurotransmitter released, the number of receptors available, and the specific ion channels involved.