IL21R
The IL21R gene encodes the interleukin-21 receptor (IL-21R), a protein that plays a critical role in the immune system. Interleukin-21 (IL-21) is a cytokine belonging to the common gamma-chain family, which also includes receptors for IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21R is primarily expressed on the surface of immune cells, such as natural killer (NK) cells, T cells, B cells, and dendritic cells, where it mediates the biological effects of IL-21.
IL-21 signaling through IL-21R influences various immune responses, including the proliferation and differentiation of T cells,
The IL21R gene is located on chromosome 16p11.2 in humans and spans approximately 10 kilobases. It consists
Mutations or alterations in IL21R have been studied in relation to immune dysfunction and disease susceptibility.